Acetaminophen During Pregnancy: No Link to Autism or ADHD, Study Finds

Stockholm, Sweden Svalbard and Jan Mayen
Acetaminophen is a popular pain reliever and fever reducer used during pregnancy
A new study published in JAMA found no association between acetaminophen use during pregnancy and an increased risk of these conditions in children
There has been concern about the safety of acetaminophen and its potential link to neurodevelopmental disorders such as autism and ADHD
Acetaminophen During Pregnancy: No Link to Autism or ADHD, Study Finds

Acetaminophen, the active ingredient in Tylenol, is a popular pain reliever and fever reducer that many women use during pregnancy. However, there has been some concern about its safety and potential link to neurodevelopmental disorders such as autism and ADHD. A new study published in JAMA on Tuesday found no association between acetaminophen use during pregnancy and an increased risk of these conditions in children.

The researchers analyzed the prenatal records of over 2 million Swedish children born between 1995 and 2019, comparing those who were exposed to acetaminophen with a control group. They found no evidence that taking acetaminophen during pregnancy was associated with an increased risk of autism, ADHD or intellectual disability in the offspring.

The study also included a sibling analysis that looked at pairs of siblings whose mothers used acetaminophen during one pregnancy but not the other. This analysis found no evidence that exposure to acetaminophen was associated with an increased risk of neurodevelopmental problems in children.

Overall, this study suggests that taking acetaminophen during pregnancy is safe and does not increase the risk of autism or ADHD in children.



Confidence

100%

No Doubts Found At Time Of Publication

Sources

82%

  • Unique Points
    • Acetaminophen during pregnancy not linked to autism, ADHD or intellectual disability among children
    • `The researchers ultimately concluded there was no link between the developmental disorders and acetaminophenb
    • Taking acetaminophen during pregnancy has been associated with an increased risk of autism and ADHD in some research. A new report published in JAMA on Tuesday focused on data from more than 2 million Swedish children who were followed for up to 26 years.
    • `After an initial analysis that revealed a very small increased risk of neurodevelopmental disorders in children whose mothers took acetaminophen during pregnancy, the researchers went back to the same database and did a second study, looking at pairs of siblings whose mothers used acetaminophen during one pregnancy but not the other. This time they found there was no increased risk of neurodevelopmental problems associated with acetaminophen.b
    • Acetaminophen is one of the few options women can use for pain and fever during pregnancy. Studies have shown over and over again it is a safe drug to take during pregnancy, even in high doses.
    • aNot treating fevers in moms could also be a problem as studies have linked untreated fevers during pregnancy to an increased risk of autism.
  • Accuracy
    • A new study published in the JAMA Network on Tuesday found that use of acetaminophen during pregnancy is not linked to an increased risk of autism, attention-deficit/hyperactivity disorder (ADHD) or intellectual disability among children
    • `The researchers ultimately concluded there was no link between the developmental disorders and acetaminophen`
  • Deception (100%)
    None Found At Time Of Publication
  • Fallacies (85%)
    None Found At Time Of Publication
  • Bias (85%)
    The author uses language that implies a causal relationship between acetaminophen and autism, ADHD, and intellectual disability. The use of the phrase 'crude absolute risks' also suggests a causal link when in fact it is not possible to establish cause from observational data.
    • A new study suggested that the use of acetaminophen during pregnancy is not linked to an increased risk of autism, attention-deficit/hyperactivity disorder (ADHD) or intellectual disability among children.
    • Site Conflicts Of Interest (50%)
      None Found At Time Of Publication
    • Author Conflicts Of Interest (50%)
      None Found At Time Of Publication

    82%

    • Unique Points
      • Acetaminophen during pregnancy not associated with ADHD or autism risk
      • Taking acetaminophen during pregnancy has been associated with an increased risk of autism and ADHD in children in some research. A new report published in JAMA on Tuesday focused on data from more than 2 million Swedish children who were followed for up to 26 years.
      • After an initial analysis that revealed a very small increased risk of neurodevelopmental disorders in children whose mothers took acetaminophen during pregnancy, the researchers went back to the same database and did a second study, looking at pairs of siblings whose mothers used acetaminophen during one pregnancy but not the other. This time they found there was no increased risk of neurodevelopmental problems associated with acetaminophen.
      • Both the initial and sibling studies were published in the same report. In this study as well as in earlier ones, researchers have had little information on whether the parents themselves had autism, ADHD or an intellectual disability.
    • Accuracy
      • Taking acetaminophen during pregnancy has been associated with an increased risk of autism and ADHD in children in some research.
      • A new study published in JAMA on Tuesday focused on data from more than 2 million Swedish children who were followed for up to 26 years.
    • Deception (50%)
      The article is deceptive in that it presents a study which found no association between acetaminophen use during pregnancy and an increased risk of autism or ADHD. However, the author then goes on to present other studies which have found such associations. This creates confusion for readers who may believe that there is still a link between acetaminophen use during pregnancy and these conditions.
      • The article states that taking acetaminophen during pregnancy has been associated with an increased risk of autism, and ADHD in children in some research. However, the author then presents a study which found no association between acetaminophen use during pregnancy and an increased risk of these conditions.
      • The article mentions studies which have linked fevers during pregnancy to an increased risk of autism. This creates confusion for readers who may believe that there is still a link between acetaminophen use during pregnancy and these conditions.
    • Fallacies (90%)
      None Found At Time Of Publication
    • Bias (85%)
      The article suggests that acetaminophen during pregnancy is not associated with an increased risk of autism or ADHD. However, the study found a small increased risk of neurodevelopmental disorders in children whose mothers took acetaminophen during pregnancy. The researchers went back to the same database and did a second study looking at pairs of siblings whose mothers used acetaminophen during one pregnancy but not the other, finding no increased risk associated with acetaminophen. However, this does not rule out that there may be other factors contributing to these disorders.
      • Taking acetaminophen during pregnancy has been associated with an increased risk of autism and ADHD in children in some research.
      • Site Conflicts Of Interest (100%)
        None Found At Time Of Publication
      • Author Conflicts Of Interest (0%)
        None Found At Time Of Publication

      85%

      • Unique Points
        • Acetaminophen use during pregnancy was not associated with increased risk of autism, ADHD or intellectual disability in children.
        • `The researchers ultimately concluded there was no link between the developmental disorders and acetaminophen`
        • Taking acetaminophen during pregnancy has been associated with an increased risk of autism and ADHD in some research. A new report published in JAMA on Tuesday focused on data from more than 2 million Swedish children who were followed for up to 26 years.
        • `Both the initial and sibling studies were published in the same report.a
        • Acetaminophen is one of the few options women can use for pain and fever during pregnancy. Studies have shown over and over again it is a safe drug to take during pregnancy, even in high doses.
        • bNot treating fevers in moms could also be a problem as studies have linked untreated fevers during pregnancy to an increased risk of autism.
      • Accuracy
        • `Both the initial and sibling studies were published in the same reporta
      • Deception (100%)
        None Found At Time Of Publication
      • Fallacies (85%)
        The article contains several fallacies. The author uses an appeal to authority by citing the JAMA study as evidence that acetaminophen use during pregnancy is safe. However, this study does not provide conclusive evidence and has limitations such as a small sample size and potential confounding factors. Additionally, the author quotes experts who have previously stated that there is an increased risk of autism, ADHD, and intellectual disability associated with acetaminophen use during pregnancy without providing any context or explanation for these statements. This creates confusion and misinformation for readers. The article also contains a false dilemma by presenting only two options: either acetaminophen use is safe or it is not. However, there may be other factors to consider when making decisions about medication use during pregnancy.
        • The author uses an appeal to authority by citing the JAMA study as evidence that acetaminophen use during pregnancy is safe.
      • Bias (100%)
        None Found At Time Of Publication
      • Site Conflicts Of Interest (50%)
        None Found At Time Of Publication
      • Author Conflicts Of Interest (50%)
        The author has a conflict of interest on the topic of acetaminophen use in pregnancy as they are reporting on a study that found no association between acetaminophen use and neurodevelopmental impairment. The author is also affiliated with CNN which may have financial ties to pharmaceutical companies.
        • The article mentions the study's extensive design, which may suggest that it was funded by a pharmaceutical company.
          • The article reports on a study conducted by the University of California, San Francisco (UCSF) that found no association between acetaminophen use and neurodevelopmental impairment in children born in Sweden between 1995 and 2019. The author does not disclose any financial ties to UCSF or pharmaceutical companies.