In a groundbreaking medical development, the world's first successful transplant of a genetically-edited pig kidney was performed on Richard Slayman at Massachusetts General Hospital (MGH) on March 16, 2023. Slayman, a Weymouth resident and former manager with the state Department of Transportation, had been suffering from end-stage kidney disease and had previously undergone a human kidney transplant in 2018 that eventually failed. Due to recurrent dialysis complications requiring frequent hospital visits for de-clotting and surgical revisions, Slayman's nephrologist and the MGH Transplant Center team suggested a pig kidney transplant as an option.
The pig donor was genetically edited using technology to remove harmful pig genes and add certain human genes. Scientists also deactivated porcine endogenous retroviruses in the pig donor to eliminate any risk of infection in humans. Slayman underwent a successful surgery, and on April 3, he was released from the hospital with one of the cleanest bills of health he had experienced in a long time.
However, less than two months later, on May 11 or 12 (sources vary), Slayman passed away suddenly. Massachusetts General Hospital confirmed his death and expressed deep sadness at the loss. Slayman's family also released a statement expressing their gratitude for the hospital team that gave them seven more weeks with their beloved Rick.
Slayman's transplant marked a significant milestone in xenotransplantation, which refers to healing human patients with cells, tissues, or organs from animals. Such efforts have long failed due to the human immune system's immediate rejection of foreign animal tissue. Recent attempts involve pigs that have been modified so their organs are more humanlike.
The first genetically-edited pig kidney transplant was a potential solution to reduce the global organ shortage, with over 100,000 people on the national waiting list for a transplant and thousands dying each year before their turn comes. However, this tragic event raises questions about the safety and long-term effects of xenotransplantation.
Massachusetts General Hospital is deeply saddened by Slayman's passing but has no indication that it was the result of his recent transplant. The hospital offers its heartfelt condolences to Slayman's family and loved ones as they remember an extraordinary person whose generosity and kindness touched all who knew him.
