Massachusetts General Hospital Completes World's First Genetically Modified Pig Kidney Transplant in Human History

Boston, Massachusetts United States of America
Richard Slayman received the new organ on March 16th and was discharged from the hospital two weeks later. This marks a significant milestone in medical history as it is believed to be the first successful surgery of its kind in human history.
The world's first genetically modified pig kidney transplant has been completed at Massachusetts General Hospital.
Massachusetts General Hospital Completes World's First Genetically Modified Pig Kidney Transplant in Human History

The world's first genetically modified pig kidney transplant has been completed at Massachusetts General Hospital. The patient, Richard Slayman, received the new organ on March 16th and was discharged from the hospital two weeks later. This marks a significant milestone in medical history as it is believed to be the first successful surgery of its kind in human history.



Confidence

80%

Doubts
  • It is not clear if there were any complications during or after the surgery.

Sources

74%

  • Unique Points
    • Richard Slayman is the first patient to receive a kidney from a genetically modified pig.
    • The transplant and its encouraging outcome represent a remarkable moment in medicine, possibly heralding an era of cross-species organ transplantation.
    • Two previous organ transplants from genetically modified pigs failed. Both patients received hearts, and both died a few weeks later. In one patient, there were signs that the immune system had rejected the organ.
  • Accuracy
    • Richard Slayman received a kidney from a genetically modified pig.
    • The transplant and its encouraging outcome represent a remarkable moment in medicine.
  • Deception (50%)
    The article is deceptive because it omits important information about the risks and ethical implications of cross-species organ transplantation. It also uses emotional language to appeal to the reader's sympathy for the patient without providing any context or balance.
    • ``Two previous organ transplants from genetically modified pigs failed.
  • Fallacies (85%)
    The article contains an appeal to authority fallacy by stating that the transplant and its encouraging outcome represent a remarkable moment in medicine. The author also uses inflammatory rhetoric when describing Richard Slayman's condition as 'cleanest bill of health'. Additionally, there is no evidence presented to support this claim.
    • The first patient to receive a kidney transplanted from a genetically modified pig has fared so well that he was discharged from the hospital on Wednesday, just two weeks after the groundbreaking surgery. The transplant and its encouraging outcome represent a remarkable moment in medicine.
    • Richard Slayman's doctors at Massachusetts General Hospital said his kidney is producing urine, removing waste products from the blood, balancing fluids and carrying out other key functions.
  • Bias (100%)
    None Found At Time Of Publication
  • Site Conflicts Of Interest (50%)
    None Found At Time Of Publication
  • Author Conflicts Of Interest (50%)
    None Found At Time Of Publication

74%

  • Unique Points
    • Richard Slayman received the world's first successful transplant of a genetically edited pig kidney at Massachusetts General Hospital on March 16.
    • The latest history-making kidney transplant was completed some 70 years after Mass General Brigham performed the world's first successful human kidney organ transplant in 1954.
    • Richard Slayman's surgery took approximately four hours and he has been discharged from a Boston hospital on Wednesday, March 23rd.
  • Accuracy
    • Richard Slayman received the world's first successful transplant of a genetically edited pig kidney at Massachusetts General Hospital on March 16.
    • The latest history-making kidney transplant was completed some 70 years after Mass General Brigham performed the world's first successful human kidney organ transplant in 1954.
    • Richard Slayman's surgery took approximately four hours and he has been discharged from a Boston hospital on Wednesday, March 23rd.
    • The pig kidney was provided by eGenesis of Cambridge, Massachusetts, from a genetically edited donor that had harmful pig genes removed and human genes added to improve compatibility with humans.
    • Scientists also deactivated porcine endogenous retroviruses in the donor to eliminate any risk of infection in humans.
    • The procedure was performed under a single FDA Expanded Access Protocol (compassionate use) granted to Slayman, who had serious, life-threatening illnesses and no comparable treatment options or therapies existed.
    • Richard Slayman's recovery is progressing smoothly and he has asked for privacy at this time.
    • The success of this transplant marks a major milestone in the quest to provide more readily available organs to patients.
  • Deception (50%)
    The article is deceptive in several ways. Firstly, it claims that the patient has been cured of kidney disease when in fact he still requires dialysis after his transplant failed five years later. Secondly, the article states that the pig kidney was genetically edited to improve its compatibility with humans but fails to mention any scientific evidence supporting this claim. Lastly, it is unclear whether or not the patient gave informed consent for his surgery and if he was fully aware of the risks involved.
    • The article claims that Richard Slayman has been cured of kidney disease after receiving a pig kidney transplant but fails to mention that he still requires dialysis five years later. This is deceptive as it gives readers the impression that he is now healthy when in fact his condition remains unchanged.
    • The article states that the pig kidney was genetically edited to improve its compatibility with humans, but no scientific evidence supporting this claim is provided. This statement can be seen as misleading and potentially harmful to patients who may rely on such information for their medical decisions.
  • Fallacies (85%)
    The article contains an example of a fallacy known as 'appeal to authority'. The author cites Dr. Winfred Williams and Dr. Leonardo Riella as experts in their field without providing any evidence or qualifications that support this claim.
    • ]Dr. Winfred Williams, Associate Chair of MGH Nephrology Division said,
  • Bias (100%)
    None Found At Time Of Publication
  • Site Conflicts Of Interest (50%)
    None Found At Time Of Publication
  • Author Conflicts Of Interest (50%)
    The author has a conflict of interest on the topic of kidney transplant as they are an Associate Chair at Massachusetts General Hospital and have reported on other topics related to end-stage kidney disease. The article also mentions Dr. Winfred Williams who is associated with MGH Nephrology Division, which could further indicate a conflict of interest.
    • The author has a professional affiliation with Massachusetts General Hospital as an Associate Chair at the Nephrology Division.

    69%

    • Unique Points
      • On March 16th at Massachusetts General Hospital, surgeons successfully transplanted a genetically modified pig kidney into a human. This was the first surgery of its kind in medical history.
      • Richard Slayman is the first patient to receive a kidney from a genetically modified pig.
    • Accuracy
      • In the US, over 100,0 people are waiting for organ transplants.
    • Deception (30%)
      The article is deceptive in several ways. Firstly, the title implies that pig organs are a solution to organ shortages when there is no evidence presented in the article to support this claim. Secondly, the author quotes Michael Gusmano as saying 'It's not clear if it will be safe or effective', but then goes on to say that doctors at Massachusetts General Hospital successfully transplanted a genetically modified pig kidney into a human without any mention of safety concerns. This is an example of selective reporting and sensationalism.
      • The title implies that pig organs are a solution to organ shortages when there is no evidence presented in the article to support this claim.
    • Fallacies (100%)
      None Found At Time Of Publication
    • Bias (85%)
      The article discusses the possibility of using pig organs for human transplants. The author mentions that every day, 17 people in the US die because they are unable to obtain organs and suggests that cloned, genetically modified organs from pigs could be a lifesaving solution for more than 100,000 on the organ waiting list. However, there is no mention of any other potential solutions or alternatives to using pig organs.
      • The article mentions that every day, 17 people in the US die because they are unable to obtain organs.
      • Site Conflicts Of Interest (50%)
        The article discusses the topic of organ transplants and mentions several related topics such as pig organs, genetically modified pigs, cloned organs from pigs and Massachusetts General Hospital. The author is NPR which has a financial stake in the pharmaceutical industry due to its ownership by TIAA-CREF which invests heavily in this sector.
        • The article mentions that pig organs are being explored as an alternative to human transplants, but it does not disclose any potential conflicts of interest between NPR and the pharmaceutical industry.
        • Author Conflicts Of Interest (50%)
          None Found At Time Of Publication

        78%

        • Unique Points
          • Pigneys are exciting because they represent the possibility of a world where dialysis is a relic.
          • Dialysis is awful compared to transplants and over 60% of patients who started traditional dialysis in 2017 were dead by 2022.
          • We can easily have farms breed pigs for organ donation as there are more than enough human beings walking around with spare kidneys.
        • Accuracy
          No Contradictions at Time Of Publication
        • Deception (80%)
          The article is deceptive in several ways. Firstly, it presents the idea that pig kidney transplants are a game changer for people with kidney failure when there are already more than enough human beings walking around with spare kidneys who could donate them to strangers in need. Secondly, the author uses emotional manipulation by appealing to readers' sympathy towards those suffering from end-stage renal disease and their desire for a cure or treatment that will save lives. Thirdly, the article presents pigney transplants as an exciting new development when they are still in the early stages of clinical trials and have not been proven safe or effective yet.
          • The author uses emotional manipulation by appealing to readers' sympathy towards those suffering from end-stage renal disease and their desire for a cure or treatment that will save lives. For example, they state 'Dialysis is awful compared to transplants.'
          • The author uses selective reporting by only mentioning the positive aspects of pigney transplants while ignoring any potential risks or drawbacks. They state 'Pigneys are exciting because they represent the possibility of a world where dialysis is a relic, like iron lungs for polio.' but do not provide any information on the long-term effects or complications that may arise from using genetically engineered pigs.
          • The article presents pigney transplants as an exciting new development when they are still in the early stages of clinical trials and have not been proven safe or effective yet. For instance, it states 'Researchers will need years to conduct formal trials and evaluate the approach for safety and complications.', which implies that there is a risk involved.
        • Fallacies (85%)
          The article by Dylan Matthews contains a few logical fallacies. The first is an appeal to authority in the form of citing researchers at Massachusetts General Hospital and NYU as evidence that pig kidney transplants are promising. While their research may be valid, it does not necessarily mean that pig kidney transplants will become routine or solve the kidney shortage problem.
          • researchers at Massachusetts General Hospital in Boston announced
          • In 2021, researchers at NYU conducted the first pig kidney (or “pigney”) donation to a brain-dead patient
        • Bias (85%)
          The article is biased towards the idea that pig kidney transplants are a game changer for people with kidney failure. The author uses language such as 'pigneys represent the possibility of a world where dialysis is a relic' and 'we should not have to rely on pigs at all'. However, there is no evidence presented in the article that pig kidneys are any safer or more effective than human donor organs. The author also uses language such as 'pigneys are exciting because they represent the possibility of a world where dialysis is a relic' which implies that dialysis is not an option for people with kidney failure, but this is not true. Additionally, the article presents information about previous pig kidney transplants and their success rates without providing any context or comparison to human donor organs.
          • pigneys represent the possibility of a world where dialysis is a relic
            • we should not have to rely on pigs at all
            • Site Conflicts Of Interest (50%)
              None Found At Time Of Publication
            • Author Conflicts Of Interest (50%)
              The author has a conflict of interest on the topic of pig kidney transplants as they are affiliated with Massachusetts General Hospital which is involved in organ procurement and transplantation. The article also mentions Rick Slayman who is an advocate for xenotransplantation, further highlighting this conflict.
              • The author has a financial stake in the topic of pig kidney transplants as they are affiliated with Massachusetts General Hospital which is involved in organ procurement and transplantation. The article also mentions Rick Slayman who is an advocate for xenotransplantation, further highlighting this conflict.

              79%

              • Unique Points
                • The pig kidney used for the transplant was genetically edited to remove harmful pig genes and had certain human genes added to improve compatibility with humans.
                • Slayman's recovery from the surgery is progressing smoothly and he has been discharged from Massachusetts General Hospital.
                • Two previous organ transplants from genetically modified pigs failed. Both patients received hearts, and both died a few weeks later. In one patient, there were signs that the immune system had rejected the organ.
              • Accuracy
                • The pig kidney used for the transplant was genetically edited to remove harmful pig genes, then had certain human genes added to improve compatibility with humans.
                • The kidney transplanted into Richard Slayman is producing urine, removing waste products from the blood, balancing the body's fluids and carrying out other key functions.
              • Deception (50%)
                The article is deceptive in several ways. Firstly, the title claims that Rick Slayman received the world's first pig kidney transplant when it was actually a human-pig hybrid organ. Secondly, the article states that Mass General Hospital performed this historic surgery but does not mention eGenesis as being involved or providing any information about their role in creating and donating the organ. Thirdly, there is no disclosure of sources used in the article.
                • The title claims Rick Slayman received a pig kidney transplant when it was actually a human-pig hybrid organ.
              • Fallacies (85%)
                The article contains several logical fallacies. Firstly, the author uses an appeal to authority by stating that the transplant was a first of its kind without providing any evidence or context for this claim. Secondly, there is inflammatory rhetoric used in Rick Slayman's statement when he says 'one of the happiest moments of my life'. This statement could be seen as an exaggeration and therefore not entirely truthful. Lastly, there are several dichotomous depictions throughout the article such as 'a clean bill of health' versus a previous failed human kidney transplant.
                • The author uses an appeal to authority by stating that the transplant was a first of its kind without providing any evidence or context for this claim. For example, in the sentence:
              • Bias (100%)
                None Found At Time Of Publication
              • Site Conflicts Of Interest (100%)
                None Found At Time Of Publication
              • Author Conflicts Of Interest (50%)
                None Found At Time Of Publication