A new hormonal gel for male birth control, which men apply on their shoulders, has shown promising results in clinical trials. The gel, which contains testosterone and a synthetic hormone called Nestorone, effectively reduces sperm production within an average of eight weeks.
The findings come from several studies conducted by various organizations such as the National Institute of Child Health and Human Development (NICHD), the Population Council, and the University of Washington School of Medicine. In one study involving 222 men, 86% achieved effective contraception within this time frame.
The gel is considered a significant advancement in male birth control options as previous methods like vasectomy and condoms have limitations. Vasectomy is not easily reversible, while condoms have low acceptance rates due to various reasons such as inconvenience and effectiveness concerns.
Researchers are continuing to evaluate the safety, acceptability, and long-term effects of the gel. They also plan to communicate with regulatory agencies like the US Food and Drug Administration about a phase 3 trial design.
The rapidity of sperm suppression is surprising as it suppresses 50% by eight weeks and 85-90% by 15 weeks, which is much faster than the typical sperm life cycle of 72 days.
While hormonal methods may raise concerns for some individuals, non-hormonal options are also being explored. YourChoice Therapeutics is currently conducting a phase 1b trial for its non-hormonal pill, and Contraline plans to start trials in the US in 2025.
The development of male birth control is an essential step towards gender equality and shared responsibility in family planning. It would provide men with greater control over their reproductive health and offer more options for women who cannot use hormonal methods due to side effects or medical reasons.
