Discovery could lead to new avenues for early prevention and intervention strategies for Alzheimer's
Individuals with higher amounts of amyloid more likely to have mothers with a history of Alzheimer's disease
New study suggests maternal history of Alzheimer's increases inherited risk
Researchers analyzed 4,400 adults between ages 65 and 85 with amyloid in brain-imaging scans
In a groundbreaking study conducted by Mass General Brigham, researchers have found that having a mother with Alzheimer's disease could lead to a higher risk of inherited disease than a paternal history. This new insight into the genetic factors of Alzheimer's has significant implications for understanding and potentially preventing the onset of this devastating condition. The study analyzed 4,400 adults between ages 65 and 85 who did not have any signs of cognitive decline, but did have amyloid show up in brain-imaging scans. The individuals with the higher amounts of amyloid were more likely to have mothers with a history of Alzheimer's disease. This discovery could pave the way for new avenues of research into early prevention and intervention strategies for Alzheimer's, as well as highlighting the importance of considering sex-specific parental history in identifying adults at an increased risk. Further studies are needed to fully understand the mechanisms behind this intriguing finding and to explore its potential implications for clinical practice.
A new study from Mass General Brigham found that having a mother with Alzheimer’s could lead to a higher risk of inherited disease than a paternal history.
Maternal history of dementia increased their children’s risk of having preclinical Alzheimer’s disease while paternal history had less impact.
Accuracy
Having a mother with Alzheimer's could lead to a higher risk of inherited disease than a paternal history.
Maternal history of dementia increased their children's risk of having preclinical Alzheimer's disease while paternal history had less impact.
Deception
(100%)
None Found At Time Of
Publication
Fallacies
(95%)
The article contains an appeal to authority with the quotes from Dr. Hyun-Sik Yang and Mabel Seto, but no formal or informal fallacies were found in the author's statements.
][Dr. Hyun-Sik Yang] Our study showed a striking asymmetry in the impact of maternal versus paternal history of dementia on the risk of offsprings’ brain amyloid-beta protein accumulation, with maternal history having a greater impact.[/]
[Dr. Mabel Seto] It's interesting from a genetic perspective to see one sex contributing something the other sex isn’t.
[Dr. Hyun-Sik Yang] This stage might represent a unique opportunity to treat AD before it irreversibly destroys the brain.
Individuals with a family history of Alzheimer’s disease (AD) from their mother’s side or from both parents showed higher levels of amyloid in their brains.
Maternal history of memory impairment at all ages and paternal history of early-onset memory impairment were associated with higher amyloid levels in the asymptomatic study participants.
Accuracy
Individuals with a family history of Alzheimer’s disease from their mother’s side or from both parents showed higher levels of amyloid in their brains.
People whose mothers were diagnosed with Alzheimer’s have a higher likelihood of developing the disease than those whose fathers have it.
Deception
(80%)
The article reports on a study that suggests inheriting Alzheimer's disease risk from the maternal side is linked to higher amyloid levels in the brain. The author does not make any editorializing or pontification statements, and there is no emotional manipulation or sensationalism present. However, there are instances of selective reporting as the article only reports details that support the author's position. For example, it states 'individuals with a family history of Alzheimer’s disease (AD) from their mother’s side or from both parents showed higher levels of amyloid in their brains.' However, it fails to mention that having only a paternal history of late-onset memory impairment was not associated with higher amyloid levels. This selective reporting lowers the credibility of the article and reduces transparency for readers.
Having only a paternal history of late-onset memory impairment was not associated with higher amyloid levels.
individuals with a family history of Alzheimer’s disease (AD) from their mother’s side or from both parents showed higher levels of amyloid in their brains.
Fallacies
(95%)
The article reports on a study that found individuals with a family history of Alzheimer's disease (AD) from their mother's side or from both parents showed higher levels of amyloid in their brains. The author does not commit any formal or informal fallacies, but there are some instances of inflammatory rhetoric and appeals to authority. However, these do not significantly impact the overall quality of the article.
][Hyun-Sik Yang] Our study found if participants had a family history on their mother's side, a higher amyloid level was observed.[/
][Mabel Seto] It's really interesting from a genetic perspective to see one sex contributing something the other sex isn't.[/
People whose mothers were diagnosed with Alzheimer’s have a higher likelihood of developing the disease than those whose fathers have it.
Mitochondria, the minuscule powerhouses within our cells, could be a factor in why patients with dementia mothers are at a higher risk as mitochondria are inherited from the mother’s side.
Defects in the X chromosome could also be responsible for the increased risk of Alzheimer’s for those with mothers diagnosed with the disease.
Accuracy
No Contradictions at Time
Of
Publication
Deception
(70%)
The article makes a statement about the higher likelihood of developing Alzheimer's if one's mother had the disease compared to if their father did. This is an example of selective reporting as it only reports details that support the author's position and ignores other relevant information, such as the increased risk for those whose fathers were diagnosed before 65. The article also implies a causal relationship between having a mother with Alzheimer's and developing the disease without providing any peer-reviewed studies to back up this claim.
People whose mothers were diagnosed with Alzheimer’s are more likely to develop the disease than those whose fathers have it
The study discovered that participants with higher levels of amyloid plaques were more likely to have a family history of the disease from their mother’s side.
