Despite updated guidelines discouraging the use of aspirin for primary prevention of cardiovascular disease among older adults due to increased bleeding risk, a significant number continue to consume it. According to recent studies, nearly one-third of adults aged 60 and above without cardiovascular disease reported using preventative aspirin in 2021. Among these individuals, approximately 3.3 million were taking the pills without medical advice (Gupta et al., 2024; CNN, 2024).
Aspirin was previously recommended by physicians to reduce the risk of heart attacks and strokes in older adults. However, today's understanding reveals that the benefits of taking aspirin for primary prevention outweigh the risks due to increased bleeding, which is more prevalent among older adults (Gupta et al., 2024). This bleeding could manifest as gastrointestinal or intracranial (CNN, 2024).
The risk-benefit balance for primary prevention applies only to the first occurrence of a cardiovascular event and not to secondary prevention, which aims at preventing repeated events. The most recent findings from clinical trials such as Ascend, Arrive, and Aspree in 2018 highlighted the benefits and harms of aspirin beyond earlier studies conducted in the 1990s (Gupta et al., 2024). Preventative treatment of cardiovascular disease has improved since then, making aspirin use today less impactful on risk. Additionally, older adults experience more bleeding than previously observed with aspirin usage (Gupta et al., 2024).
The American College of Cardiology and American Heart Association updated their guidelines in 2019 to suggest that adults aged 70 and above or those with increased bleeding risk should not take aspirin on a routine basis for primary prevention (Gupta et al., 2024; USPSTF, 2022). The U.S. Preventive Services Task Force released its updated recommendations in 2022, advising that adults aged 60 and older should not initiate aspirin for the primary prevention of cardiovascular disease (USPSTF, 2022).
Despite these updates, aspirin usage among older adults remains high. Gupta and colleagues at Creighton University and Houston Methodist observed a significant decrease in aspirin usage after 2018 as more physicians recommended stopping it (Gupta et al., 2024). However, the number of older adults taking aspirin daily still warrants concern.
It is essential for patients to discuss their cardiovascular disease prevention methods with their healthcare providers. While daily aspirin may not be suitable for all older adults, alternative evidence-based methods such as managing obesity, quitting smoking, and regularly screening for high blood pressure and metabolic diseases can help prevent the first heart attack or stroke (Wong, 2024).