A section of genetic code acts as a macrophage's role in IBD and other immune disorders.
Researchers from Francis Crick Institute, UCL, and Imperial College London discovered a major driver of inflammatory bowel disease (IBD) and several other immune disorders.
The discovery provides new insights into the pathogenesis of these conditions.
In a groundbreaking discovery, researchers from the Francis Crick Institute, in collaboration with UCL and Imperial College London, have identified a major driver of inflammatory bowel disease (IBD) and several other immune disorders that affect the spine, liver, and arteries. This finding is significant as it provides new insights into the pathogenesis of these conditions and opens up opportunities for developing targeted treatments.
The researchers discovered that a section of genetic code, or DNA, acts as a macrophage's
Researchers have discovered a major driver of inflammatory bowel disease (IBD) and several other immune disorders that affect the spine, liver and arteries.
Approximately 5% of humans live with an autoimmune or inflammatory disease.
, Genetics provides a unique opportunity to address the high failure rate in developing effective treatments for immune-mediated diseases.
, Hundreds of loci are now directly linked to the pathogenesis of immune-mediated diseases.
, Drugs that target pathways implicated by genetics have a higher chance of being effective.
, An intergenic region on chromosome 21q22 is a notable example of a region where the major allele haplotype predisposes to five inflammatory diseases.
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No Contradictions at Time
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None Found At Time Of
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No formal fallacies found. Some informal fallacies and inflammatory rhetoric present. Dichotomous depictions and appeals to authority not found.
]This high failure rate is mainly due to a lack of efficacy[
Indeed, drugs that target pathways implicated by genetics have a far higher chance of being effective10.
Unfortunately, most risk variants do not lie in coding DNA, but in less-well-conserved, non-coding genomic regions.
UK scientists discovered a weak spot in DNA that is present in 95% of people with inflammatory bowel disease (IBD).
Dr James Lee discovered a section of genetic code, or DNA, that acts as the macrophage’s ‘master regulator’ of inflammation.
Existing drugs have been found to reverse the disease in laboratory experiments for IBD.
Symptoms of IBD include diarrhea, stomach pain or cramps, blood in poo, bleeding from your bottom, fatigue, and losing weight without trying.
Accuracy
The gene controls the suite of inflammatory chemicals macrophages release, and some people are born with a version that makes their body prone to responding excessively.
Crohn’s disease and ulcerative colitis are estimated to affect half a million people in the UK.
One part of the immune system highly implicated in IBD are white blood cells called macrophages that flood intestinal linings and release chemicals causing inflammation.
The researchers aim to start clinical trials within five years to test the effectiveness of existing drugs in targeting just the macrophages and calibrating them to calm IBD without leaving a patient susceptible to infection.
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None Found At Time Of
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The article contains an appeal to authority fallacy when Dr. James Lee states 'This is undoubtedly one of the central pathways that goes wrong for people to get inflammatory bowel disease.' and 'It is the process by which one of the most important cells that causes inflammatory bowel disease goes wrong.', as well as an inflammatory rhetoric when stating 'potentially a new way of treating these diseases' and 'a really exciting step towards the possibility of a world free from Crohn’s and colitis one day.'
This is undoubtedly one of the central pathways that goes wrong for people to get inflammatory bowel disease.
It is the process by which one of the most important cells that causes inflammatory bowel disease goes wrong.
potentially a new way of treating these diseases
a really exciting step towards the possibility of a world free from Crohn’s and colitis one day.
Scientists are exploring the use of a cancer drug to treat bowel disease (unique article does not provide any other facts about the specific drug or how it works)
Researchers at the Francis Crick Institute, working with UCL and Imperial College London, have made a discovery in inflammatory bowel disease.
Accuracy
Researchers at the Francis Crick Institute, working with UCL and Imperial College London, have made a discovery of a major cause of inflammatory bowel disease.
Approximately 5% of humans live with an autoimmune or inflammatory disease.
UK scientists discovered a weak spot in DNA that is present in 95% of people with inflammatory bowel disease.
Deception
(100%)
None Found At Time Of
Publication
Fallacies
(95%)
The author makes several statements that are not fallacies but rather reporting facts. The author also quotes individuals who express their personal experiences and opinions, which are valid to report on. However, there is one instance of an appeal to authority fallacy when the author states 'Using genetics as a starting point, we’ve uncovered a pathway that appears to play a major role in IBD and other inflammatory diseases.' This statement implies that because the researchers used genetics as their starting point, their findings are automatically valid and significant. However, this does not necessarily mean that the findings are correct or significant without further evidence. Therefore, while there is no explicit dichotomous depiction or inflammatory rhetoric in the article, there is one instance of an appeal to authority fallacy.
Using genetics as a starting point, we’ve uncovered a pathway that appears to play a major role in IBD and other inflammatory diseases.
